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Yue-Ming Li Selected Research

Amyloid Precursor Protein Secretases (beta-Secretase)

10/2022Hypoxia Inducible Factor-1α binds and activates γ-secretase for Aβ production under hypoxia and cerebral hypoperfusion.
1/2022Turning the tide on Alzheimer's disease: modulation of γ-secretase.
11/2021Imaging of Cancer γ-Secretase Activity Using an Inhibitor-Based PET Probe.
1/2021GSAP regulates lipid homeostasis and mitochondrial function associated with Alzheimer's disease.
10/2020The innate immunity protein IFITM3 modulates γ-secretase in Alzheimer's disease.
9/2020Recent developments of small molecule γ-secretase modulators for Alzheimer's disease.
1/2020A Pentacyclic Triterpene from Ligustrum lucidum Targets γ-Secretase.
1/2020γ-Secretase inhibitors and modulators: Mechanistic insights into the function and regulation of γ-Secretase.
1/2020γ-Secretase Modulatory Proteins: The Guiding Hand Behind the Running Scissors.
1/2020Epac1 inhibition ameliorates pathological angiogenesis through coordinated activation of Notch and suppression of VEGF signaling.
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Yue-Ming Li Research Topics

Disease

43Alzheimer Disease (Alzheimer's Disease)
01/2022 - 02/2002
18Neoplasms (Cancer)
01/2022 - 12/2004
5Amyloid Plaque
10/2020 - 01/2006
4Neuroinflammatory Diseases
01/2022 - 12/2017
3Hypoxia (Hypoxemia)
10/2022 - 01/2014
3Brain Neoplasms (Brain Tumor)
01/2022 - 08/2006
3Inflammation (Inflammations)
01/2022 - 01/2019
2Neoplasm Metastasis (Metastasis)
01/2022 - 08/2014
2Breast Neoplasms (Breast Cancer)
11/2021 - 08/2014
2Down Syndrome (Down's Syndrome)
01/2021 - 04/2019
2Carcinogenesis
11/2020 - 01/2009
2Pancreatic Neoplasms (Pancreatic Cancer)
06/2013 - 04/2009
1Brain Hypoxia (Cerebral Hypoxia)
10/2022
1Melanosis (Freckles)
07/2022
1Pain (Aches)
07/2022
1Melanoma (Melanoma, Malignant)
01/2022
1Glioblastoma (Glioblastoma Multiforme)
11/2021
1Acquired Immunodeficiency Syndrome (AIDS)
11/2020
1Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
11/2020
1Pathologic Neovascularization
01/2020
1Gliosis
12/2017
1Pancreatitis
06/2013
1Autoimmune Pancreatitis
06/2013
1Thrombosis (Thrombus)
07/2010
1Heart Valve Diseases (Valvular Heart Disease)
07/2010
1Thromboembolism
07/2010
1Hematologic Neoplasms (Hematological Malignancy)
04/2010
1Glioma (Gliomas)
01/2010
1Hepatocellular Carcinoma (Hepatoma)
10/2009
1Colonic Neoplasms (Colon Cancer)
01/2009
1Neuroblastoma
02/2007
1Medulloblastoma
08/2006

Drug/Important Bio-Agent (IBA)

40Amyloid Precursor Protein Secretases (beta-Secretase)IBA
10/2022 - 02/2002
19Proteins (Proteins, Gene)FDA Link
01/2022 - 11/2002
17Amyloid (Amyloid Fibrils)IBA
10/2020 - 11/2002
15Amyloid beta-PeptidesIBA
10/2022 - 07/2003
13Peptides (Polypeptides)IBA
01/2014 - 11/2002
7Pharmaceutical PreparationsIBA
01/2022 - 12/2004
3Peptide Hydrolases (Proteases)FDA Link
10/2022 - 11/2002
3Biological ProductsIBA
01/2020 - 07/2010
3PresenilinsIBA
03/2016 - 01/2009
3EnzymesIBA
08/2014 - 04/2010
3Presenilin-1IBA
05/2012 - 02/2002
2O-(glucuronic acid 2- sulfate)- (1- - 4)- O- (2,5)- anhydromannitol 6-sulfateIBA
08/2015 - 04/2013
2Gamma Secretase Inhibitors and ModulatorsIBA
01/2010 - 01/2009
1Erlotinib Hydrochloride (CP 358,774)FDA Link
01/2022
1salicylhydroxamic acid (SHAM)IBA
11/2021
1LipidsIBA
01/2021
1Staphylococcal Protein A (Protein A)IBA
01/2021
1CalciumIBA
11/2020
1dolutegravirIBA
11/2020
1Reactive Oxygen Species (Oxygen Radicals)IBA
11/2020
1InterferonsIBA
10/2020
1TriterpenesIBA
01/2020
1erythromycin propionate-N-acetylcysteinateIBA
01/2020
1Indoleamine-Pyrrole 2,3,-Dioxygenase (Indoleamine 2,3 Dioxygenase)IBA
01/2020
1Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
01/2020
1CarbamatesIBA
01/2020
1Oxygen (Dioxygen)IBA
01/2020
1Oleanolic AcidIBA
01/2020
1Aspartic Acid ProteasesIBA
01/2017
1benzimidazoleIBA
01/2016
1Protein Isoforms (Isoforms)IBA
01/2016
1Transcription Factors (Transcription Factor)IBA
08/2014
1Kazal Pancreatic Trypsin InhibitorIBA
06/2013
1Serine Proteases (Serine Protease)IBA
06/2013
1AmylasesFDA Link
06/2013
1TrypsinIBA
06/2013
1BMS 708163IBA
09/2012
1Membrane Proteins (Integral Membrane Proteins)IBA
06/2011
1Flavin-Adenine Dinucleotide (FAD)IBA
12/2010
1Dimethyl Sulfoxide (DMSO)FDA LinkGeneric
01/2010
1Indicators and Reagents (Reagents)IBA
01/2010
1PolymersIBA
01/2010
1Small Molecule LibrariesIBA
10/2009
1NF-kappa B (NF-kB)IBA
10/2009
1LigandsIBA
04/2009
1Aldehyde DehydrogenaseIBA
04/2009
1Oxaliplatin (Eloxatin)FDA LinkGeneric
01/2009
1Presenilin-2IBA
08/2007
1Small Interfering RNA (siRNA)IBA
02/2007
1Pyridinolcarbamate (P23)IBA
02/2007
1AgarIBA
08/2006
1Coloring Agents (Dyes)IBA
08/2006

Therapy/Procedure

9Therapeutics
01/2022 - 11/2002
2Oral Administration
09/2010 - 10/2009
1Lasers (Laser)
07/2022
1Solid-State Lasers
07/2022
1Ligation
01/2020
1Immunotherapy
01/2020
1Prostheses and Implants (Prosthesis)
07/2010
1Drug Therapy (Chemotherapy)
01/2009